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PMID: 7978855 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats.

Annals of the New York Academy of Sciences ·Vol. 732 ·1994-09-06 ·Pages 96-111

Golub LM, Evans RT, McNamara TF, Lee HM, Ramamurthy NS

Abstract

暂无摘要

MeSH Terms

Animals Bacteroidaceae Infections/drug therapy,physiopathology Bone Resorption/prevention & control Collagenases/metabolism Doxycycline/therapeutic use Enzyme Activation Gelatinases/metabolism Gingiva/enzymology Male Matrix Metalloproteinase Inhibitors Metalloendopeptidases/antagonists & inhibitors,metabolism Pancreatic Elastase/metabolism Periodontitis/drug therapy,physiopathology Porphyromonas gingivalis Rats Rats, Sprague-Dawley Tetracycline/therapeutic use

Chemicals

Matrix Metalloproteinase Inhibitors 4-des-dimethylaminotetracycline Pancreatic Elastase Collagenases Gelatinases Metalloendopeptidases Tetracycline Doxycycline

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Golub L M

Department of Oral Biology & Pathology, School of Dental Medicine, State University of New York at Stony Brook 11794-8702.

Evans R T

McNamara T F

Lee H M

Ramamurthy N S

Article Info

Journal

Annals of the New York Academy of Sciences

Abbr.

Ann N Y Acad Sci

ISSN

0077-8923

DOI

10.1111/j.1749-6632.1994.tb24728.x

Published

1994-09-06

Pages

96-111

Language

English

Region

United States

NLM ID

7506858

Subset

Grants

NIDCR NIH HHS · RE37 DE-03987 · United States

External Links

PubMed source DOI: 10.1111/j.1749-6632.1994.tb24728.x View journal details

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A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats.

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