Structure, assembly and function of mammalian alpha-keto acid dehydrogenase complexes.

Advances in biophysics ·1976-00-00 ·Pages 187-227

Koike M, Koike K

Abstract

An attempt has been made to provide a description of the mammalian alpha-keto acid dehydrogenase multienzyme complexes, especially with respect to the structure, assembly and function of PDC and OGDC based on the investigation carried out in this laboratory over the last 14 years. Special efforts have been focused on the purification, characterization, and stoichiometric resolution into component enzymes, and the reassembling process to produce these multienzyme complexes. Studies of the macroorganization and the mechanism of regulation of these multienzyme complexes still remains a most challenging question.

MeSH Terms

Acetyltransferases/analysis Allosteric Regulation Amino Acids/analysis Animals Binding Sites Cations, Divalent Coenzymes/analysis Diffusion Dihydrolipoamide Dehydrogenase/analysis Ketoglutarate Dehydrogenase Complex/analysis Ketone Oxidoreductases/analysis Kinetics Methods Microscopy, Electron Mitochondria/enzymology Molecular Weight Multienzyme Complexes/analysis,isolation & purification Myocardium/enzymology Pyruvate Dehydrogenase Complex/analysis Structure-Activity Relationship Swine Thiamine Pyrophosphate/analysis Ultracentrifugation

Chemicals

Amino Acids Cations, Divalent Coenzymes Multienzyme Complexes Pyruvate Dehydrogenase Complex Ketone Oxidoreductases Ketoglutarate Dehydrogenase Complex Dihydrolipoamide Dehydrogenase Acetyltransferases Thiamine Pyrophosphate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Koike M

Koike K

Article Info

Journal

Advances in biophysics

Abbr.

Adv Biophys

ISSN

0065-227X

Published

1976-00-00

Pages

187-227

Language

English

Region

Japan

NLM ID

0262476

Subset

External Links

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Structure, assembly and function of mammalian alpha-keto acid dehydrogenase complexes.

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