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题目:: Induction of bcl-2 gene expression by intercellular information from hemopoietic supportive stromal cells to DA-1 cells.
作者:: Takashita(E),Sugimoto(K),Adachi(Y),Mori(K J)
状态:: 发布时间1994-12-28 , 更新时间 2003-11-14
期刊:: J Cell Physiol
摘要:: When interleukin-3 (IL-3) dependent DA-1 cells were cultured on hemopoietic supportive stromal cells (MS-5), DA-1 cells survived and proliferated in the absence of detectable IL-3. Although IL-3 was not produced by the MS-5 cells, their production of granulocyte-macrophage colony-stimulating factor (GM-CSF) was increased when they were co-cultured with DA-1 cells. This suggests that DA-1 cells transmit signals to stromal cells that enhance growth factor(s) production. Expression of bcl-2 by DA-1 cells was induced when they were co-cultured with MS-5 cells, suggesting that DA-1 cells express bcl-2 strongly in response to a signal produced by MS-5 cells. These data indicate the existence of a two-way interaction between DA-1 cells and hemopoietic supportive stromal cells.
语言:: eng
DOI:: 10.1002/jcp.1041610222

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