The B-cell antigen receptor complex: structure and signal transduction.

Immunology today ·Vol. 15 ·No. 9 ·1994-09-00 ·Pages 393-9

Pleiman CM, D'Ambrosio D, Cambier JC

Abstract

The specificity of the immune response is determined by the interaction between the B-cell receptor (BCR) and its cognate structure, antigen. Recent studies have provided considerable insight into the compartmentalization of function within this extremely versatile hetero-oligomeric receptor complex. In this article, Christopher Pleiman, Daniele D'Ambrosio and John Cambier consolidate new findings regarding BCR structure and signal transduction.

MeSH Terms

Amino Acid Sequence Animals Enzyme Precursors/immunology Humans Intracellular Signaling Peptides and Proteins Molecular Sequence Data Protein-Tyrosine Kinases/immunology Receptors, Antigen, B-Cell/chemistry,immunology Signal Transduction/immunology Syk Kinase

Chemicals

Enzyme Precursors Intracellular Signaling Peptides and Proteins Receptors, Antigen, B-Cell Protein-Tyrosine Kinases SYK protein, human Syk Kinase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Pleiman C M

National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80220.

D'Ambrosio D

Cambier J C

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(94)90267-4

Published

1994-09-00

Pages

393-9

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(94)90267-4

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