Home LiteratureArticle Details
PMID: 7942859 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The power of interval mapping of quantitative trait loci, using selected sib pairs.

American journal of human genetics ·Vol. 55 ·No. 4 ·1994-10-00 ·Pages 825-33

Cardon LR, Fulker DW

Abstract

The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.

MeSH Terms
Algorithms Alleles Gene Frequency Genes, Recessive Genetic Carrier Screening Genetics, Medical/methods Genotype Humans Mathematics Models, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cardon L R
Department of Mathematics, Stanford University, CA 94305.
Fulker D W
References (9)
9 references, click to expand
  1. The investigation of linkage between a quantitative trait and a marker locus.
    Behav Genet. 1972 Mar;2(1):3-19 PMID: 4157472
  2. Linkage between marker loci and those affecting a quantitative trait.
    Behav Genet. 1973 Dec;3(4):389-91 PMID: 4776435
  3. Multiple regression analysis of twin data.
    Behav Genet. 1985 Sep;15(5):467-73 PMID: 4074272
  4. Multiple regression analysis of twin data obtained from selected samples.
    Genet Epidemiol. 1986;3(6):425-33 PMID: 3803912
  5. A sib-pair approach to interval mapping of quantitative trait loci.
    Am J Hum Genet. 1994 Jun;54(6):1092-103 PMID: 8198132
  6. A more powerful robust sib-pair test of linkage for quantitative traits.
    Genet Epidemiol. 1989;6(3):435-49 PMID: 2753353
  7. Multipoint analysis of human quantitative genetic variation.
    Am J Hum Genet. 1990 Dec;47(6):957-67 PMID: 2239972
  8. Linkage analysis of quantitative traits: increased power by using selected samples.
    Am J Hum Genet. 1991 Oct;49(4):786-96 PMID: 1897525
  9. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.
    Genetics. 1989 Jan;121(1):185-99 PMID: 2563713
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1994-10-00
Pages
825-33
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1918307
Subset
IM
Grants
NICHD NIH HHS · NICHD HD-11681 · United States
NICHD NIH HHS · NICHD HD-27802 · United States
NIDA NIH HHS · NIDA DA05131 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2