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PMID: 7934844 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Secondary-sites for integration mediated by the Tn21 integrase.

Molecular microbiology ·Vol. 10 ·No. 4 ·1993-11-00 ·Pages 823-8

Francia MV, de la Cruz F, García Lobo JM

Abstract

The integrase encoded by the integron of the transposon Tn21 can mediate the site-specific fusion of two plasmids if there is a recombination hot spot (59 bp element) in one of them and the sequence GWTMW in the other. The use of this latter, loosely defined site explains how antibiotic-resistance genes could first become associated with integrons.

MeSH Terms

Base Sequence Binding Sites/genetics DNA Nucleotidyltransferases/genetics,metabolism DNA Transposable Elements DNA, Bacterial/genetics Escherichia coli/enzymology,genetics Integrases Molecular Sequence Data Plasmids/genetics Recombination, Genetic

Chemicals

DNA Transposable Elements DNA, Bacterial DNA Nucleotidyltransferases Integrases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Francia M V

Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain.

de la Cruz F

García Lobo J M

Article Info

Journal

Molecular microbiology

Abbr.

Mol Microbiol

ISSN

0950-382X

DOI

10.1111/j.1365-2958.1993.tb00952.x

Published

1993-11-00

Pages

823-8

Language

English

Region

England

NLM ID

8712028

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2958.1993.tb00952.x View journal details

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