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PMID: 793408 Published · ppublish English Journal Article Review

Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. I. Lesions associated with mesangial IgM deposits.

The American journal of pathology ·Vol. 85 ·No. 2 ·1976-11-00 ·Pages 277-302

Bolton WK, Benton FR, Maclay JG, Sturgill BC

Abstract

The present studies examined the pathogenesis of focal glomerular sclerosis in aging rats. A marked difference in development of the lesion was noted between males and females, and strain variability was an important factor. Increased glomerular basement membrane permeability with loss of selectivity unrelated to changes in glomerular sialoprotein occurred with aging and was accompanied by increasing proteinuria. Noncomplement-fixing mesangial deposits of rat IgM were present after 1 month of age and were also found in lesser amounts in germfree rats. Fluoresceinated eluates of rat kidneys did not have antibody activity against rat serum or tissue antigens. There was no evidence for a pathogenetic role of IgM deposits. Rat IgG, IgA, IgE, C3, and fibrin were occasionally found in sclerotic areas. Analysis of multiple histologic sections revealed a close correlation between aging and glomerular pathology, with a poor correlation between tubular damage and aging. Glomerular damage appeared to be the initial event leading to tubular damage. Indirect evidence suggests that a relative thymic deficiency may play an important role in the pathogenesis of the lesion.

MeSH Terms
Aging Animals Animals, Newborn Complement Fixation Tests Female Immunoglobulin A Immunoglobulin E Immunoglobulin G Immunoglobulin M/metabolism Kidney Glomerulus/physiopathology Male Nephrosclerosis/etiology,physiopathology,veterinary Proteinuria Rats Rodent Diseases/etiology,physiopathology
Chemicals
Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulin E
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bolton W K
Benton F R
Maclay J G
Sturgill B C
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48 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1976-11-00
Pages
277-302
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032571
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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