Muscle differentiation. Which myogenic factors make muscle?

Current biology : CB ·Vol. 4 ·No. 1 ·1994-01-01 ·Pages 61-3

Buckingham M

Abstract

Mice lacking myogenin have little skeletal muscle as fibres fail to differentiate. Lack of both MyoD and myf-5 results in no skeletal muscle and apparently no myoblasts, suggesting that these factors act earlier in muscle development.

MeSH Terms

Animals Cell Differentiation DNA-Binding Proteins Embryonic and Fetal Development Gene Expression Mice Mice, Mutant Strains Muscle Fibers, Skeletal/physiology Muscle Proteins/biosynthesis,physiology Muscles/cytology,embryology,physiology MyoD Protein/biosynthesis,physiology Myogenic Regulatory Factor 5 Myogenin/physiology Trans-Activators Transcription Factors/physiology

Chemicals

DNA-Binding Proteins Muscle Proteins Myf5 protein, mouse MyoD Protein Myog protein, mouse Myogenic Regulatory Factor 5 Myogenin Trans-Activators Transcription Factors

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Buckingham M

Department of Molecular Biology, Pasteur Institute, CNRS ERS 67, Paris, France.

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(00)00014-2

Published

1994-01-01

Pages

61-3

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(00)00014-2 View journal details

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Muscle differentiation. Which myogenic factors make muscle?

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