The mode of action of aspirin and similar compounds.

The Journal of allergy and clinical immunology ·Vol. 58 ·No. 6 ·1976-12-00 ·Pages 691-712

Vane JR

Abstract

Aspirin-like drugs inhibit the biosynthesis of prostaglandins in all tissues and species so far studied. The concentrations necessary for this action are achieved after therapeutic dosage. The evidence is reviewed which establishes this biochemical action as the basic mode of therapeutic action of aspirin-like drugs as anti-inflammatory, analgesic, and antipyretic compounds. It may also account for the shared side effects, including the hypersensitivity to aspirin-like drugs shown by some allergic patients.

MeSH Terms

Anti-Inflammatory Agents/pharmacology Arachidonic Acids/metabolism Aspirin/pharmacology Bronchi/drug effects Dermatitis, Atopic/immunology Drug Hypersensitivity/immunology Edema/etiology Erythema/etiology Fever/etiology Humans Hypersensitivity/etiology Inflammation/drug therapy Pain/etiology Prostaglandin Antagonists Prostaglandins/metabolism Prostaglandins E/pharmacology Prostaglandins F/pharmacology Respiratory Hypersensitivity/immunology Uveitis/immunology

Chemicals

Anti-Inflammatory Agents Arachidonic Acids Prostaglandin Antagonists Prostaglandins Prostaglandins E Prostaglandins F Aspirin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Vane J R

Article Info

Journal

The Journal of allergy and clinical immunology

Abbr.

J Allergy Clin Immunol

ISSN

0091-6749

DOI

10.1016/0091-6749(76)90181-0

Published

1976-12-00

Pages

691-712

Language

English

Region

United States

NLM ID

1275002

Subset

External Links

PubMed source DOI: 10.1016/0091-6749(76)90181-0 View journal details

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The mode of action of aspirin and similar compounds.

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