The modification and assembly of proteins in the endoplasmic reticulum.

Current opinion in cell biology ·Vol. 5 ·No. 4 ·1993-08-00 ·Pages 589-95

Gaut JR, Hendershot LM

Abstract

Proteins fold and assemble in the endoplasmic reticulum in an environment that is very different from the cytosol. The presence of relatively high concentrations of calcium, an oxidizing state, ATP and lumenal proteins are all important in mediating these events.

MeSH Terms

Animals Chaperonins Chemical Phenomena Chemistry, Physical Endoplasmic Reticulum/chemistry,metabolism Humans Membrane Proteins/chemistry,metabolism Peptides/metabolism Protein Folding Proteins/chemistry

Chemicals

Membrane Proteins Peptides Proteins Chaperonins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Gaut J R

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

Hendershot L M

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/0955-0674(93)90127-c

Published

1993-08-00

Pages

589-95

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/0955-0674(93)90127-c View journal details

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The modification and assembly of proteins in the endoplasmic reticulum.

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