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PMID: 7898608 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Is there an energy conservation "system" in brain that protects against the consequences of energy depletion?

Neurochemical research ·Vol. 19 ·No. 11 ·1994-11-00 ·Pages 1393-400

Pazdernik T, Cross R, Nelson S, Kamijo Y, Samson F

Abstract

A poorly understood marked decrease (circa 50% of control) in local cerebral glucose utilization is caused by sublethal doses of NaCN. The decrease is global, occurring in essentially all brain regions and is entirely reversible within hours, leaving no obvious pathology. This event is not unique to NaCN in so far as a strikingly similar pattern of decreased glucose utilization occurs with some other toxins. Nor can it be attributed to a direct action of NaCN since local application by microdialysis to the striatum produces a global depression. These results imply that some widely distributed "system" or substance is involved. We speculate the existence of a "system" possibly related to the reticular activating system that senses a fall in energy production and acts globally to make cells quiescent and thus would give some protection from excitotoxic driven damage.

MeSH Terms

Analysis of Variance Animals Autoradiography Brain/drug effects,metabolism Carbon Radioisotopes Deoxyglucose/metabolism Energy Metabolism/drug effects Kinetics Lactates/metabolism Microdialysis Organ Specificity Perfusion Pyruvates/metabolism Rats Rats, Wistar Reference Values Sodium Cyanide/toxicity

Chemicals

Carbon Radioisotopes Lactates Pyruvates Deoxyglucose Sodium Cyanide

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Pazdernik T

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160-7336.

Cross R

Nelson S

Kamijo Y

Samson F

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Article Info

Journal

Neurochemical research

Abbr.

Neurochem Res

ISSN

0364-3190

DOI

10.1007/BF00972468

Published

1994-11-00

Pages

1393-400

Language

English

Region

United States

NLM ID

7613461

Subset

Grants

NICHD NIH HHS · 2 P30 HD02528 · United States

External Links

PubMed source DOI: 10.1007/BF00972468 View journal details

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Is there an energy conservation "system" in brain that protects against the consequences of energy depletion?

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