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PMID: 7896769 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Mitochondrial cation transport: a progress report.

Journal of bioenergetics and biomembranes ·Vol. 26 ·No. 5 ·1994-10-00 ·Pages 537-42

Garlid KD

Abstract

This report summarizes recent work in our laboratory aimed at understanding protein-mediated mitochondrial cation transport. We are studying three distinct cation cycles that contain porters catalyzing influx and efflux of cations between cytosol and mitochondrial matrix. Each of these cation cycles plays a major physiological role in the overall energy economy. The K+ cycle maintains the integrity of the vesicular structure and includes the K+/H+ antiporter, the KATP channel, and K+ leak driven by the high membrane potential. The Ca2+ cycle relays the signals calling for modulation of ATP production and includes the Ca2+ channel, the Na+/Ca2+ antiporter, and the Na+/H+ antiporter. The H+ cycle of brown adipose tissue mitochondria provides heat to hibernating and newborn mammals and consists of the uncoupling protein, which catalyzes regulated H+ influx.

MeSH Terms
Adipose Tissue, Brown/physiology Animals Biological Transport Calcium/metabolism Carrier Proteins/metabolism Cations/metabolism Homeostasis Hydrogen-Ion Concentration Ion Channels Membrane Proteins/metabolism Mitochondria/metabolism Mitochondrial Proteins Models, Biological Uncoupling Protein 1
Chemicals
Carrier Proteins Cations Ion Channels Membrane Proteins Mitochondrial Proteins Uncoupling Protein 1 Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Garlid K D
Department of Chemistry, Biochemistry, and Molecular Biology, Oregon Graduate Institute of Science and Technology, Portland 97291-1000.
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Article Info
Journal
Journal of bioenergetics and biomembranes
Abbr.
J Bioenerg Biomembr
ISSN
0145-479X
DOI
10.1007/BF00762738
Published
1994-10-00
Pages
537-42
Language
English
Region
United States
NLM ID
7701859
Subset
IM
Grants
NIGMS NIH HHS · GM 31086 · United States
NHLBI NIH HHS · HL 36573 · United States
NHLBI NIH HHS · HL 43814 · United States
External Links
PubMed source DOI: 10.1007/BF00762738 View journal details
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