Home LiteratureArticle Details
PMID: 7891487 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma.

Lancet (London, England) ·Vol. 345 ·No. 8952 ·1995-03-25 ·Pages 759-61

Huang YQ, Li JJ, Kaplan MH, Poiesz B, Katabira E, Zhang WC, Feiner D, Friedman-Kien AE

Abstract

The association between a new human herpesvirus-like agent and various forms of Kaposi's sarcoma was examined by PCR. The DNA sequences of this agent were detected in 7 of 8 classic Kaposi's sarcoma specimens, 12 of 12 AIDS-associated specimens from the United States, and 7 of 10 specimens from African endemic Kaposi's sarcoma. Polymorphism of the herpesvirus-like DNA in the Kaposi's tissue from different populations was observed by both single-strand conformational polymorphism and direct sequencing. Furthermore, the presence and expression of the virus was detected in some Kaposi's tumours by Southern and northern blotting. This herpesvirus may be involved in the pathogenesis of different kinds of Kaposi's sarcoma seen among distinct and unrelated populations.

MeSH Terms
Acquired Immunodeficiency Syndrome/complications Base Sequence Blotting, Northern Blotting, Southern DNA Primers DNA, Viral/genetics Herpesviridae/genetics Humans Polymerase Chain Reaction Polymorphism, Genetic Sarcoma, Kaposi/virology
Chemicals
DNA Primers DNA, Viral
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Huang Y Q
Department of Dermatology, New York University Medical Center, New York 10016.
Li J J
Kaplan M H
Poiesz B
Katabira E
Zhang W C
Feiner D
Friedman-Kien A E
Article Info
Journal
Lancet (London, England)
Abbr.
Lancet
ISSN
0140-6736
DOI
10.1016/s0140-6736(95)90641-x
Published
1995-03-25
Pages
759-61
Language
English
Region
England
NLM ID
2985213R
Subset
IM
Databases
GENBANK
U61113, U61114, U61115, U61116, U61117, U61118, U61119, U61120, U61121, U61122, U61123, U61124, U61125, U61126, U61127, U61128, U61129, U61130, U61131, U61132, U61133, U61134, U61135, U61136, U61137, U61138
Corrections
CommentIn
PMID: 7723569
External Links
PubMed source DOI: 10.1016/s0140-6736(95)90641-x View journal details
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