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题目:: How do colorectal cancers develop?
作者:: Kuramoto(S),Oohara(T)
状态:: 发布时间1995-04-14 , 更新时间 2010-03-24
期刊:: Cancer
摘要:: The aim of this study was to reveal (1) whether a flat adenoma is the precursor of a flat cancer and (2) the more frequent pathway in colorectal cancer development-a flat cancer or a polypoid cancer.,Clinical features and histologic characteristics of 97 flat early cancers, 138 polypoid early cancers, 60 advanced cancers involving the muscularis propria, and 185 flat adenomas were investigated.,Of the flat cancers, 89.7% were not accompanied by residual adenoma and are considered to have arisen de novo. The distribution of flat adenomas and flat cancers was significantly different, and a follow-up of flat adenomas did not reveal any rapid growth or carcinomatous changes in the flat adenomas. The shape of advanced cancers involving only the muscularis propria almost matches that of flat early cancers. Fifty-two of 97 flat cancers and 19 of 138 polypoid cancers invaded the submucosal layer.,Flat adenomas are not considered to be precursors of flat cancers. Advanced cancers of the large intestine originate mainly from flat cancers arising de novo. The percentage of the advanced cancers that originate from flat cancers is estimated to be 71.2% (52 of 52 +/- 19) at a minimum.
语言:: eng
DOI:

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