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PMID: 7884912 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy.

Journal of virology ·Vol. 69 ·No. 4 ·1995-04-00 ·Pages 2611-6

Renjifo B, Borrero I, Essex M

Abstract

Tumaco, Colombia, is an area with elevated rates of tropical spastic paraparesis/human T-cell leukemia virus type I (HTLV-I)-associated myelopathy (TSP/HAM). We have identified a mutation in nucleotide 7959 of the tax gene of 14 Tumaco HTLV-I isolates (14 positive of 14 tested) that was present in 5 of 14 (35%) TSP/HAM patients from Japan and in 8 of 11 (72%) TSP/HAM patients from other geographic locations. In contrast, this mutation was found in only 2 of 21 (9.5%) HTLV-I-infected subjects outside of Tumaco who did not have TSP/HAM. tax clones with nucleotide mutations including one at nucleotide 7959 showed a greater ability to transactivate the HTLV-I U3 promoter. However, this effect was not observed when two clones that differed only in nucleotide 7959 were compared. These results suggest that HTLV-I-infected individuals carrying isolates with this tax mutation are at higher risk for developing TSP/HAM.

MeSH Terms
Colombia/epidemiology DNA, Viral Genes, pX Human T-lymphotropic virus 1/genetics Humans Mutation Paraparesis, Tropical Spastic/epidemiology,virology
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Renjifo B
Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115.
Borrero I
Essex M
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41 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.4.2611-2616.1995
Published
1995-04-00
Pages
2611-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC188940
Subset
IM
Grants
NCI NIH HHS · CA39805 · United States
Corrections
ErratumIn
-
CommentIn
PMID: 7637041
External Links
PubMed source DOI: 10.1128/JVI.69.4.2611-2616.1995 PMC Full Text View journal details
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