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PMID: 7884761 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

A review of the mechanisms of oral tolerance and immunotherapy.

Journal of the Royal Society of Medicine ·Vol. 88 ·No. 1 ·1995-01-00 ·Pages 14-7

Sosroseno W

Abstract

The induction of oral tolerance by oral immunization has been well recognized. Accumulated evidence shows that oral tolerance can be mediated by orally activated humoral and cellular factors. In animal models, the development of several T cell-mediated autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, uveitis and diabetes type 1 can be inhibited by oral immunization of the respective antigens. In allergy, oral administration of certain allergens can prevent and reduce both contact and atopic dermatitis. Oral tolerance to alloantigen also reduces graft rejection. In spite of these encouraging results, the usefulness of this approach for an alternative immunotherapy in humans needs to be investigated further.

MeSH Terms
Administration, Oral Autoimmune Diseases/therapy Humans Hypersensitivity/therapy Immune Tolerance Immunosuppression Therapy Immunotherapy T-Lymphocytes/immunology T-Lymphocytes, Regulatory/immunology Transplantation Immunology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sosroseno W
Department of Dental Public Health, Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Indonesia.
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37 references, click to expand
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Article Info
Journal
Journal of the Royal Society of Medicine
Abbr.
J R Soc Med
ISSN
0141-0768
Published
1995-01-00
Pages
14-7
Language
English
Region
England
NLM ID
7802879
PMCID
PMC1295066
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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