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PMID: 7871025 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Anatomical differentiation within the nucleus accumbens of the locomotor stimulatory actions of selective dopamine agonists and d-amphetamine.

Psychopharmacology ·Vol. 112 ·No. 2-3 ·1993-00-00 ·Pages 233-41

Essman WD, McGonigle P, Lucki I

Abstract

The effects of local injections of dopamine receptor agonists into various areas within the nucleus accumbens or the medial caudate-putamen on the generation of locomotor activity were examined. Combinations of 0.32 microgram/side of the dopamine receptor agonists SKF 38393 (D1) and quinpirole (D2) produced increases in locomotor activity that varied according to the rostral-caudal placement of the cannulae within the nucleus accumbens. The greatest levels of locomotion were generated by injections into a region in the caudal-central nucleus accumbens, with lower levels of activity elicited by injections into more rostral or caudal regions. A similar pattern of responses was produced by administration of the indirect dopamine agonist d-amphetamine. These results indicate that there is marked heterogeneity in the response of discrete sub-regions of the nucleus accumbens to dopamine receptor stimulation and that this heterogeneity is functionally expressed in the mediation of the locomotor effects of dopaminergic agonists.

MeSH Terms
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology Animals Dextroamphetamine/pharmacology Dopamine Agonists/pharmacology Ergolines/pharmacology Male Motor Activity/drug effects Nucleus Accumbens/anatomy & histology,physiology Quinpirole Rats Rats, Sprague-Dawley Receptors, Dopamine D1/agonists Receptors, Dopamine D2/agonists
Chemicals
Dopamine Agonists Ergolines Receptors, Dopamine D1 Receptors, Dopamine D2 Quinpirole 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine Dextroamphetamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Essman W D
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-2649.
McGonigle P
Lucki I
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF02244916
Published
1993-00-00
Pages
233-41
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
Grants
NIGMS NIH HHS · GM 34781 · United States
External Links
PubMed source DOI: 10.1007/BF02244916 View journal details
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