Mechanisms of sexual transmission of HIV: does HIV infect intact epithelia?

Trends in microbiology ·Vol. 2 ·No. 11 ·1994-11-00 ·Pages 454-8

Phillips DM, Zacharopoulos VR, Tan X, Pearce-Pratt R

Abstract

The prevailing view of sexual transmission of HIV has been that the virus enters the body through lesions in the epithelium of the genital tract. We propose that transmission of HIV can occur via the infection of intact epithelial cells, and that it is mediated by HIV-infected mononuclear cells in genital-tract secretions.

MeSH Terms

CD4-Positive T-Lymphocytes/ultrastructure,virology Cell Adhesion Epithelium/virology Genitalia/virology HIV/pathogenicity HIV Infections/transmission,virology Humans Microscopy, Electron Microscopy, Electron, Scanning Sexually Transmitted Diseases, Viral/transmission,virology

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Phillips D M

Population Council, New York, NY 10021.

Zacharopoulos V R

Tan X

Pearce-Pratt R

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/0966-842x(94)90804-4

Published

1994-11-00

Pages

454-8

Language

English

Region

England

NLM ID

9310916

Subset

External Links

PubMed source DOI: 10.1016/0966-842x(94)90804-4 View journal details

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Mechanisms of sexual transmission of HIV: does HIV infect intact epithelia?

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