The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro.

Agents and actions ·Vol. 8 ·No. 3 ·1978-04-00 ·Pages 199-202

Sharpe TJ, Ross JW, Spicer BA

Abstract

A nitroindanedione (BRL 10833) inhibited the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from passively sensitized human lung at similar concentrations to those required for the inhibition of histamine release by disodium cromoglycate (DSCG). BRL 10833 was more potent than DSCG as an inhibitor of histamine release by antigen from actively and passively sensitized rat peritoneal cells and rat skin fragments.

MeSH Terms

Animals Antigens Cells, Cultured Cromolyn Sodium/pharmacology Histamine Release/drug effects Humans Indans/therapeutic use Indenes/therapeutic use Leukocytes/metabolism Lung/metabolism Male Passive Cutaneous Anaphylaxis/drug effects Rats SRS-A/metabolism Skin/drug effects

Chemicals

Antigens Indans Indenes SRS-A nivimedone Cromolyn Sodium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Sharpe T J

Ross J W

Spicer B A

References (8)

8 references, click to expand

Disodium cromoglycate. Activity in three in vitro models of the immediate hypersensitivity reaction in lung.
Int Arch Allergy Appl Immunol. 1970;38(2):217-24 PMID: 4189435
IgE and IgGa antibody-mediated release of histamine from rat peritoneal cells. I. Optimum conditions for in vitro preparation of target cells with antibody and and challenge with antigen.
J Exp Med. 1971 Apr 1;133(4):752-71 PMID: 4100657
Increased vascular permeability during passive peritoneal anaphylaxis in the rat. The effects of disodium cromoglycate and a nitroindanedione.
Int Arch Allergy Appl Immunol. 1976;51(2):226-37 PMID: 58838
Procedures for immunochemical study of histamine release from leukocytes with small volume of blood.
J Allergy. 1970 Jul;46(1):12-20 PMID: 4193180
An automated fluorimetric assay for the rapid determination of histamine in biological fluids.
Life Sci II. 1973 Apr 8;12(7):327-36 PMID: 4121709
Interrelationship of cyclic nucleotides and anaphylactic reactions.
Nature. 1977 Feb 10;265(5594):545-7 PMID: 64936
Antiallergic activity of 2-nitroindan-1,3-diones.
J Med Chem. 1973 Dec;16(12):1334-9 PMID: 4128900
Inhibition of immediate hypersensitivity reactions in the rat by disodium cromoglycate and nitroindanedione.
Clin Exp Immunol. 1975 Sep;21(3):419-29 PMID: 812623

Article Info

Journal

Agents and actions

Abbr.

Agents Actions

ISSN

0065-4299

DOI

10.1007/BF01966603

Published

1978-04-00

Pages

199-202

Language

English

Region

Switzerland

NLM ID

0213341

Subset

External Links

PubMed source DOI: 10.1007/BF01966603

Analysis Services

The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro.

Contact

WeChat Official Account