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PMID: 7857740 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Increased circulating cytokines in patients with myocarditis and cardiomyopathy.

British heart journal ·Vol. 72 ·No. 6 ·1994-12-00 ·Pages 561-6

Matsumori A, Yamada T, Suzuki H, Matoba Y, Sasayama S

Abstract

To elucidate the potential role of cytokines in the pathogenesis of cardiomyopathy and myocarditis. Experimental studies show that certain cytokines depress myocardial contractility and that tumour necrosis factor-alpha plays an important part in the pathogenesis of myocardial injury in animal models of viral and autoimmune myocarditis. Plasma interleukin 1-alpha, interleukin 1-beta, interleukin-2, interleukin-6, tumour necrosis factor-alpha, tumour necrosis factor-beta, granulocyte-macrophage colony stimulating factor, granulocyte colony stimulating factor, macrophage colony stimulating factor, interferon-alpha and interferon-gamma were measured in 13 patients with acute myocarditis, 23 patients with dilated cardiomyopathy, 51 patients with hypertrophic cardiomyopathy, nine patients with acute myocardial infarction, 18 patients with angina pectoris, 12 patients with essential hypertension and 17 healthy controls. Increased concentrations of cytokines were not detected in the controls. In patients with acute myocarditis, interleukin 1-alpha was detected in 23% (mean (SD) 25 (11) pg/ml), tumour necrosis factor-alpha in 46% (61 (31) pg/ml), and macrophage colony stimulating factor was 2.5 (1.8) ng/ml (normal 1.9 (0.4)). In patients with dilated cardiomyopathy, tumour necrosis factor-alpha was detected in 35% (402 (555) pg/ml). In patients with hypertrophic cardiomyopathy, interleukin-2 was detectable in 14% (2318 (4738) pg/ml) and tumour necrosis factor-alpha ws detected in 20% (992 (1517) pg/ml). The concentration of macrophage colony stimulating factor was raised in patients with acute myocardial infarction. Granulocyte colony stimulating factor was often increased in myocarditis, cardiomyopathies, acute myocardial infarction, and angina pectoris--suggesting activation of macrophages and/or endothelial cells--but this increase was not specific to these diseases. Increased concentrations of cytokines were not found in patients with essential hypertension. These results suggest that cytokines may play a part in the pathogenesis of myocardial injury in myocarditis and cardiomyopathies and that further studies to explore the potential pathogenetic role of cytokines in myocardial diseases may be warranted.

MeSH Terms
Adult Aged Angina Pectoris/blood Cardiomyopathy, Dilated/blood Cardiomyopathy, Hypertrophic/blood Cytokines/blood Female Granulocyte-Macrophage Colony-Stimulating Factor/blood Humans Hypertension/blood Interferon-alpha/blood Interferon-gamma/blood Interleukin-1/blood Interleukin-2/blood Interleukin-6/blood Macrophage Colony-Stimulating Factor/blood Male Middle Aged Myocardial Infarction/blood Myocarditis/blood Tumor Necrosis Factor-alpha/metabolism
Chemicals
Cytokines Interferon-alpha Interleukin-1 Interleukin-2 Interleukin-6 Tumor Necrosis Factor-alpha Macrophage Colony-Stimulating Factor Interferon-gamma Granulocyte-Macrophage Colony-Stimulating Factor
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Matsumori A
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Yamada T
Suzuki H
Matoba Y
Sasayama S
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Article Info
Journal
British heart journal
Abbr.
Br Heart J
ISSN
0007-0769
DOI
10.1136/hrt.72.6.561
Published
1994-12-00
Pages
561-6
Language
English
Region
England
NLM ID
0370634
PMCID
PMC1025643
Subset
IM
External Links
PubMed source DOI: 10.1136/hrt.72.6.561 PMC Full Text View journal details
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