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PMID: 7855597 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.

Science (New York, N.Y.) ·Vol. 267 ·No. 5201 ·1995-02-24 ·Pages 1166-9

Szankasi P, Smith GR

Abstract

Exonuclease I (Exo I) from Schizosaccharomyces pombe, a 5'-->3' double-stranded DNA exonuclease, is induced during meiotic prophase I. The exo1 gene is a member of a family of related DNA repair genes, including RAD2/rad13/xpgc and YKL510/rad2, conserved from yeast to humans. An exo1 mutant displays a mutator phenotype and alters activity of the ade6-M387 marker effect. These results suggest that Exo I acts in a pathway that corrects mismatched base pairs.

Related Genes

exo1

MeSH Terms

Alleles Amino Acid Sequence Base Composition Base Sequence Crosses, Genetic DNA Repair DNA Replication DNA, Fungal/metabolism Exodeoxyribonucleases/chemistry,genetics,metabolism Meiosis Molecular Sequence Data Mutation Recombination, Genetic Schizosaccharomyces/enzymology,genetics,physiology

Chemicals

DNA, Fungal Exodeoxyribonucleases exodeoxyribonuclease I

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Szankasi P

Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

Smith G R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.7855597

Published

1995-02-24

Pages

1166-9

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIGMS NIH HHS · GM32194 · United States

NCI NIH HHS · P30 CA15704-20 · United States

Databases

GENBANK

L35174

External Links

PubMed source DOI: 10.1126/science.7855597 View journal details

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A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.

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