Cytoplasmic inheritance of antimycin A resistance in Saccharomyces cerevisiae.

Molecular & general genetics : MGG ·Vol. 146 ·No. 2 ·1976-07-23 ·Pages 133-7

Michaelis G

Abstract

Three antimycin resistant mutants of Saccharomyces cerevisiae are characterized genetically. The mutations have been shown to be cytoplasmically inherited by four criteria. The phenotype persists in diploids formed by a cross with a pO strain of yeast of the opposite mating type. Diploids heterozygous for the antimycin marker, however, show segregation of the resistance and sensitivity during mitosis. Tetrad analysis indicates a non-Mendelian segregation (4:0 and 0:4) of the mutations. The antimycin marker can be eliminated by ethidium bromide treatment under conditions that should have deleted all of the mitochondrial DNA.

MeSH Terms

Antimycin A/pharmacology Crosses, Genetic Drug Resistance, Microbial Ethidium Extrachromosomal Inheritance Genotype Mutation Phenotype Saccharomyces cerevisiae/drug effects

Chemicals

Antimycin A Ethidium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Michaelis G

References (9)

9 references, click to expand

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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00268081

Published

1976-07-23

Pages

133-7

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00268081

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Cytoplasmic inheritance of antimycin A resistance in Saccharomyces cerevisiae.

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