Differences in human immunodeficiency virus type 1 V3 sequences from patients with and without AIDS dementia complex.

The Journal of general virology ·Vol. 76 ( Pt 1) ·1995-01-00 ·Pages 175-80

Kuiken CL, Goudsmit J, Weiller GF, Armstrong JS, Hartman S, Portegies P, Dekker J, Cornelissen M

Abstract

Paired serum and cerebrospinal fluid (CSF) samples from 10 AIDS patients with and 10 without AIDS dementia complex (ADC) were studied, in an attempt to uncover ADC-associated variation in V3 sequences. Sequences were obtained from four of the patients with and eight of those without ADC. Comparison of the sequences using a resampling technique revealed a significant ADC-associated difference occurring at several amino acid positions. Results from serum and CSF sequences were comparable. These differences may indicate that the virus found in ADC and that in non-ADC patients have different biological properties. Comparison of serum versus CSF sequences within samples from both ADC and non-ADC patients, using the same resampling technique, revealed no clear distinctions. In some patients, the sequence populations in serum and CSF were completely distinct, while in others, there was no difference in distribution. These patterns were not associated with ADC.

MeSH Terms

AIDS Dementia Complex/blood,cerebrospinal fluid,virology Acquired Immunodeficiency Syndrome/virology Amino Acid Sequence HIV Envelope Protein gp120/chemistry HIV-1/chemistry Humans Molecular Sequence Data

Chemicals

HIV Envelope Protein gp120

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Kuiken C L

Department of Virology, Academic Medical Centre, Amsterdam, The Netherlands.

Goudsmit J

Weiller G F

Armstrong J S

Hartman S

Portegies P

Dekker J

Cornelissen M

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-76-1-175

Published

1995-01-00

Pages

175-80

Language

English

Region

England

NLM ID

0077340

Subset

Databases

GENBANK

Z37531, Z37532, Z37533, Z37534, Z37734, Z37735, Z37736, Z37737, Z37738, Z37739, Z37740, Z37741, Z37742, Z37743, Z37744, Z37745, Z37746, Z37747, Z37748, Z37749, Z37750, Z37751, Z37752, Z37753, Z37754, Z37755, Z37756, Z37757, Z37758, Z37759

External Links

PubMed source DOI: 10.1099/0022-1317-76-1-175 View journal details

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Differences in human immunodeficiency virus type 1 V3 sequences from patients with and without AIDS dementia complex.

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