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PMID: 7837 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines.

Science (New York, N.Y.) ·Vol. 193 ·No. 4256 ·1976-09-03 ·Pages 897-9

DeRubertis FR, Craven PA

Abstract

Nitrosamines markedly increase concentrations of guanosine 3', 5' - monophosphate (cyclic GMP) in several tissues from the rat and in human colonic mucosa. These agents are effective in the absence of extracellular calcium and enhance guanylate cyclase activity in tissue homogenates. Stimulation of cyclic GMP was greatest in liver, where the carcinogenic activity of nitrosamines is also most pronounced.

MeSH Terms

Animals Calcium/pharmacology Colon Cyclic GMP/metabolism Enzyme Activation Guanylate Cyclase/metabolism Humans In Vitro Techniques Intestinal Mucosa/metabolism Kidney Cortex/metabolism Liver/metabolism Lung/metabolism Male Nitrosamines/pharmacology Rats

Chemicals

Nitrosamines Guanylate Cyclase Cyclic GMP Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

DeRubertis F R

Craven P A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.7837

Published

1976-09-03

Pages

897-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.7837 View journal details

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Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines.

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