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PMID: 7833798 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Structure and functions of arrestins.

Protein science : a publication of the Protein Society ·Vol. 3 ·No. 9 ·1994-09-00 ·Pages 1355-61

Palczewski K

Abstract

Transmembrane signal transductions in a variety of cell types that mediate signals as diverse as those carried by neurotransmitters, hormones, and sensory signals share basic biochemical mechanisms that include: (1) an extracellular perturbation (neurotransmitter, hormone, odor, light); (2) specific receptors; (3) coupling proteins, such as G proteins; and (4) effector enzymes or ion channels. Parallel to these amplification reactions, receptors are precisely inactivated by mechanisms that involve protein kinases and regulatory proteins called arrestins. The structure and functions of arrestins are the focus of this review.

MeSH Terms
Amino Acid Sequence Animals Antigens Arrestin Eye Proteins Humans Molecular Sequence Data Phosphodiesterase Inhibitors Receptors, Cell Surface/metabolism Rhodopsin/metabolism Sequence Homology, Amino Acid Signal Transduction
Chemicals
Antigens Arrestin Eye Proteins Phosphodiesterase Inhibitors Receptors, Cell Surface Rhodopsin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Palczewski K
Department of Ophthalmology, University of Washington, Seattle 98195.
References (59)
59 references, click to expand
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Article Info
Journal
Protein science : a publication of the Protein Society
Abbr.
Protein Sci
ISSN
0961-8368
DOI
10.1002/pro.5560030901
Published
1994-09-00
Pages
1355-61
Language
English
Region
United States
NLM ID
9211750
PMCID
PMC2142942
Subset
IM
Grants
NEI NIH HHS · EY09339 · United States
External Links
PubMed source DOI: 10.1002/pro.5560030901 PMC Full Text View journal details
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