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PMID: 7833051 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.

Current opinion in cell biology ·Vol. 6 ·No. 5 ·1994-10-00 ·Pages 711-6

Hülsken J, Behrens J, Birchmeier W

Abstract

Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin.

MeSH Terms

Adenomatous Polyposis Coli Protein Animals Armadillo Domain Proteins Cadherins/genetics,physiology Cell Adhesion/genetics,physiology Cytoskeletal Proteins/genetics,physiology Drosophila Drosophila Proteins Genes, APC Genes, Tumor Suppressor Humans Intercellular Junctions/physiology Neoplasm Invasiveness Proteins/genetics,physiology Trans-Activators Transcription Factors beta Catenin

Chemicals

ARM protein, Drosophila Adenomatous Polyposis Coli Protein Armadillo Domain Proteins CTNNB1 protein, human Cadherins Cytoskeletal Proteins Drosophila Proteins Proteins Trans-Activators Transcription Factors beta Catenin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hülsken J

Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

Behrens J

Birchmeier W

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/0955-0674(94)90098-1

Published

1994-10-00

Pages

711-6

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/0955-0674(94)90098-1 View journal details

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Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.

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