Impairment of the immune response to vaccination after acute malaria.

Lancet (London, England) ·Vol. 1 ·No. 8078 ·1978-06-24 ·Pages 1328-9

Williamson WA, Greenwood BM

Abstract

Children with acute malaria were vaccinated with Salmonella typhi and meningococcal vaccines at varying times after the onset of their illness. The immune response to both vaccines was depressed when they were given on the day of presentation at hospital. Immune responsiveness to S. typhi vaccine was rapidly regained after treatment, but a month after the attack the immune response to meningococcal vaccine was still impaired.

MeSH Terms

Acute Disease Antibodies, Bacterial/biosynthesis Bacterial Vaccines/administration & dosage Child Child, Preschool Humans Immunologic Deficiency Syndromes/etiology Infant Malaria/immunology Neisseria meningitidis/immunology Nigeria Plasmodium falciparum Salmonella typhi/immunology Time Factors Tropical Medicine

Chemicals

Antibodies, Bacterial Bacterial Vaccines

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Williamson W A

Greenwood B M

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(78)92403-0

Published

1978-06-24

Pages

1328-9

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(78)92403-0 View journal details

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Impairment of the immune response to vaccination after acute malaria.

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