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PMID: 7806375 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Expression of the Arp protein, a member of the M protein family, is not sufficient to inhibit phagocytosis of Streptococcus pyogenes.

Infection and immunity ·Vol. 63 ·No. 1 ·1995-01-00 ·Pages 345-8

Husmann LK, Scott JR, Lindahl G, Stenberg L

Abstract

Many Streptococcus pyogenes immunoglobulin-binding proteins have structural similarities to the antiphagocytic M protein, including the well-known C repeats. One of these molecules is the immunoglobulin A-binding protein Arp, which is expressed by a serotype 4 strain for which no antiphagocytic M protein has yet been described. We expressed Arp4 in an S. pyogenes strain from which the structural gene for the M protein has been deleted and found that Arp4 is not sufficient to inhibit phagocytosis.

MeSH Terms
Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins/genetics,pharmacology Base Sequence Carrier Proteins/genetics,pharmacology Escherichia coli/genetics Fibrinogen/metabolism Gene Deletion Genes, Bacterial Humans Immunoglobulins/metabolism Molecular Sequence Data Phagocytosis/drug effects Protein Binding Recombinant Proteins/metabolism Streptococcus pyogenes/genetics,immunology
Chemicals
Antigens, Bacterial Arp4 protein, Streptococcus pyogenes Bacterial Outer Membrane Proteins Bacterial Proteins Carrier Proteins Immunoglobulins Recombinant Proteins streptococcal M protein Fibrinogen
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Husmann L K
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322.
Scott J R
Lindahl G
Stenberg L
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35 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.63.1.345-348.1995
Published
1995-01-00
Pages
345-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC172998
Subset
IM
Grants
NIAID NIH HHS · AI27023 · United States
External Links
PubMed source DOI: 10.1128/iai.63.1.345-348.1995 PMC Full Text View journal details
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