The reactivity of spleen cells from malarious rats to non-specific mitogens.

Clinical and experimental immunology ·Vol. 24 ·No. 1 ·1976-04-00 ·Pages 139-45

Spira DT, Golenser J, Gery I

Abstract

The reaction of spleen cells from rats infected with Plasmodium berghei to non-specific mitogens has been measured. The cells have been stimulated in vitro by phytohaemagglutinin, concanavalin-A and by bacterial lypopolysaccharide. In addition the release of lymphocyte activating factor (LAF) by splenic macrophages has been assayed using a heterologous thymocyte culture. The reactivity of spleen lymphocytes from malarious rats is severly affected. The cells do not react either to the T cell-specific mitogens or to the B-cell stimulant. The reactivity of macrophages, as measured by the release of LAF, was not altered by the disease.

MeSH Terms

Animals Cell Adhesion Concanavalin A Lectins Lipopolysaccharides/immunology Lymphocyte Activation Macrophages/immunology Malaria/immunology Male Plasmodium berghei/immunology Rats Rats, Inbred Lew Spleen/immunology

Chemicals

Lectins Lipopolysaccharides Concanavalin A

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Spira D T

Golenser J

Gery I

References (16)

16 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1976-04-00

Pages

139-45

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1538488

Subset

External Links

PubMed source PMC Full Text View journal details

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The reactivity of spleen cells from malarious rats to non-specific mitogens.

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