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PMID: 7774928 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23.

Genomics ·Vol. 25 ·No. 1 ·1995-01-01 ·Pages 274-8

Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K

Abstract

Replication factor C is a multimeric primer-recognition protein consisting of five subunits (p145, p40, p38, p37, and p36.5) and is essential for the processive elongation of DNA chains catalyzed by DNA polymerase delta or epsilon in human cells. We have mapped the locations on human chromosomes of the genes coding for the four smaller subunits [p36.5 (RFC5), p37 (RFC4), p38 (RFC3), and p40 (RFC2)] using both PCR amplification from DNAs of a panel of somatic hybrids and fluorescence in situ hybridization to bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23, respectively.

Related Genes

RFC2 RFC3 RFC4 RFC5

MeSH Terms

Base Sequence Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 7 Cloning, Molecular DNA Polymerase II DNA Polymerase III DNA Primers DNA Replication/genetics DNA-Binding Proteins/biosynthesis,genetics DNA-Directed DNA Polymerase/metabolism Genomic Library Homeodomain Proteins Humans In Situ Hybridization, Fluorescence Lymphocytes/cytology Macromolecular Substances Minor Histocompatibility Antigens Molecular Sequence Data Polymerase Chain Reaction Proto-Oncogene Proteins c-bcl-2 Replication Protein C Repressor Proteins Saccharomyces cerevisiae Proteins Sequence Tagged Sites

Chemicals

BCL2-related protein A1 DNA Primers DNA-Binding Proteins Homeodomain Proteins MATA1 protein, S cerevisiae Macromolecular Substances Minor Histocompatibility Antigens Proto-Oncogene Proteins c-bcl-2 RFC2 protein, human RFC3 protein, human RFC4 protein, human RFC5 protein, human Repressor Proteins Saccharomyces cerevisiae Proteins DNA Polymerase II DNA Polymerase III DNA-Directed DNA Polymerase Replication Protein C

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Okumura K

Division of Human Genome Research and Gene Bank, Tsukuba Life Science Center, Ibaraki, Japan.

Nogami M

Taguchi H

Dean F B

Chen M

Pan Z Q

Hurwitz J

Shiratori A

Murakami Y

Ozawa K

Article Info

Journal

Genomics

Abbr.

Genomics

ISSN

0888-7543

DOI

10.1016/0888-7543(95)80135-9

Published

1995-01-01

Pages

274-8

Language

English

Region

United States

NLM ID

8800135

Subset

External Links

PubMed source DOI: 10.1016/0888-7543(95)80135-9 View journal details

Analysis Services

Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23.

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