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PMID: 7774017 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family.

Cell ·Vol. 81 ·No. 5 ·1995-06-02 ·Pages 781-90

Arora K, Dai H, Kazuko SG, Jamal J, O'Connor MB, Letsou A, Warrior R

Abstract

Decapentaplegic (dpp), a TGF beta-related ligand, plays a key role in Drosophila development. Although dpp receptors have been isolated, the downstream components of the signaling pathway remain to be identified. We have cloned the schnurri (shn) gene and show that it encodes a putative zinc finger transcription factor homologous to the human major histocompatibility complex-binding proteins 1 and 2. Mutations in shn affect multiple events that require dpp signaling as well as the transcription of dpp-responsive genes. Genetic interactions and the strikingly similar phenotypes of mutations in shn and the dpp receptors encoded by thick veins and punt suggest that shn plays a downstream role in dpp signaling.

Related Genes

shn

MeSH Terms

Amino Acid Sequence Animals Base Sequence Bone Morphogenetic Proteins Cloning, Molecular DNA-Binding Proteins/genetics,metabolism Drosophila/embryology,genetics Drosophila Proteins Ectoderm/physiology Genes, Insect/genetics Histocytochemistry Insect Hormones/metabolism Mesoderm/physiology Molecular Sequence Data Mutation Proteins/genetics RNA, Messenger/genetics,isolation & purification Sequence Analysis, DNA Sequence Homology, Amino Acid Signal Transduction/genetics Tissue Distribution Tissue Transplantation Transcription Factors/genetics,metabolism Transforming Growth Factor beta/metabolism Zinc Fingers/genetics

Chemicals

Bone Morphogenetic Proteins DNA-Binding Proteins Drosophila Proteins Insect Hormones Proteins RNA, Messenger Transcription Factors Transforming Growth Factor beta dpp protein, Drosophila shn protein, Drosophila HIVEP2 protein, human

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Arora K

Department of Molecular Biology and Biochemistry, University of California, Irvine 92717, USA.

Dai H

Kazuko S G

Jamal J

O'Connor M B

Letsou A

Warrior R

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(95)90539-1

Published

1995-06-02

Pages

781-90

Language

English

Region

United States

NLM ID

0413066

Subset

Grants

NIGMS NIH HHS · GM 00599 · United States

NIGMS NIH HHS · GM 47462 · United States

NIGMS NIH HHS · GM48659 · United States

Databases

GENBANK

U31368

External Links

PubMed source DOI: 10.1016/0092-8674(95)90539-1 View journal details

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The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family.

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