The mechanisms of DNA topoisomerases.

Trends in biochemical sciences ·Vol. 20 ·No. 4 ·1995-04-00 ·Pages 156-60

Roca J

Abstract

Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.

MeSH Terms

Animals Binding Sites DNA/chemistry,metabolism DNA Topoisomerases, Type I/chemistry,classification,metabolism DNA Topoisomerases, Type II/metabolism Humans Models, Molecular

Chemicals

DNA DNA Topoisomerases, Type I DNA Topoisomerases, Type II

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Roca J

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/s0968-0004(00)88993-8

Published

1995-04-00

Pages

156-60

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/s0968-0004(00)88993-8 View journal details

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The mechanisms of DNA topoisomerases.

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