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PMID: 7768874 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene.

Journal of bacteriology ·Vol. 177 ·No. 12 ·1995-06-00 ·Pages 3601-5

Hahn J, Roggiani M, Dubnau D

Abstract

We show that the major role for Spo0A in the development of genetic competence is to downregulate expression of abrB. AbrB is both a negative regulator and a positive regulator of competence. The negative effects are exerted at multiple points in competence regulation. A regulatory mechanism that is independent of mecA and abrB operates on comK expression.

Related Genes
abrB
MeSH Terms
Bacillus subtilis/genetics Bacterial Proteins/genetics,physiology Base Sequence Cloning, Molecular DNA-Binding Proteins/genetics Down-Regulation/physiology Gene Expression Regulation, Bacterial/physiology Molecular Sequence Data Mutation Transcription Factors/genetics,physiology Transformation, Bacterial/genetics
Chemicals
AbrB protein, Bacillus subtilis Bacterial Proteins DNA-Binding Proteins Spo0A protein, Bacillus subtilis Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hahn J
Public Health Research Institute, New York, New York 10016, USA.
Roggiani M
Dubnau D
References (31)
31 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.177.12.3601-3605.1995
Published
1995-06-00
Pages
3601-5
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC177070
Subset
IM
Grants
NIAID NIH HHS · AI10311 · United States
External Links
PubMed source DOI: 10.1128/jb.177.12.3601-3605.1995 PMC Full Text View journal details
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