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PMID: 7768625 Published · ppublish English Journal Article

Porphyromonas gingivalis fimbria-stimulated bone resorption in vitro is inhibited by a tyrosine kinase inhibitor.

Infection and immunity ·Vol. 63 ·No. 6 ·1995-06-00 ·Pages 2374-7

Hanazawa S, Kawata Y, Murakami Y, Naganuma K, Amano S, Miyata Y, Kitano S

Abstract

Our previous study (Y. Kawata, S. Hanazawa, S. Amano, Y. Murakami, T. Matsumoto, K. Nishida, and S. Kitano, Infect. Immun. 62:3012-3016, 1994) showed that Porphyromonas gingivalis fimbriae stimulate bone resorption in vitro. Since it has recently been demonstrated that tyrosine kinase encoded by the c-src gene plays an important role in osteoclastic bone resorption, in the present study we examined the effect of a tyrosine kinase inhibitor on the fimbria-stimulated bone resorption. Genistein, a potent inhibitor of tyrosine kinase, markedly inhibited bone resorption stimulated by the fimbriae. Genistein also inhibited induction of several tyrosine-phosphorylated proteins in the fimbria-treated calvarial bone cells from mouse embryos.

MeSH Terms
Animals Bone Resorption/etiology,prevention & control Female Fimbriae, Bacterial/physiology Genistein Isoflavones/therapeutic use Mice Mice, Inbred ICR Porphyromonas gingivalis/pathogenicity Pregnancy Protein-Tyrosine Kinases/antagonists & inhibitors,physiology
Chemicals
Isoflavones Genistein Protein-Tyrosine Kinases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Hanazawa S
Department of Oral Microbiology, Meikai University School of Dentistry, Sakado City, Japan.
Kawata Y
Murakami Y
Naganuma K
Amano S
Miyata Y
Kitano S
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.63.6.2374-2377.1995
Published
1995-06-00
Pages
2374-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC173315
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.63.6.2374-2377.1995 PMC Full Text View journal details
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