Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells.

Bioscience, biotechnology, and biochemistry ·Vol. 58 ·No. 9 ·1994-09-00 ·Pages 1579-83

Ueda H, Nakajima H, Hori Y, Goto T, Okuhara M

Abstract

FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and inhibited their growth. The reduction of c-myc expression was observed in FR901228-treated Ras-1 cells by RNA dot-blot hybridization. This reduction of c-myc expression and morphological reversion of the transformed cells to normal were correlated with growth inhibition (G0/G1 arrest in cell cycle).

Related Genes

Ha-ras c-myc

MeSH Terms

3T3 Cells/drug effects,physiology Animals Anti-Bacterial Agents/pharmacology Antibiotics, Antineoplastic/pharmacology Blotting, Northern Cell Cycle/drug effects Cell Division/drug effects Cell Line, Transformed Cell Nucleus/drug effects,metabolism Chromobacterium/metabolism DNA, Neoplasm/biosynthesis Depsipeptides Flow Cytometry Gene Expression/drug effects Genes, myc/drug effects Genes, ras/drug effects Kinetics Macromolecular Substances Mice Peptides, Cyclic Signal Transduction/drug effects Transfection Transformation, Genetic/drug effects Urinary Bladder Neoplasms/genetics

Chemicals

Anti-Bacterial Agents Antibiotics, Antineoplastic DNA, Neoplasm Depsipeptides Macromolecular Substances Peptides, Cyclic romidepsin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Ueda H

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

Nakajima H

Hori Y

Goto T

Okuhara M

Article Info

Journal

Bioscience, biotechnology, and biochemistry

Abbr.

Biosci Biotechnol Biochem

ISSN

0916-8451

DOI

10.1271/bbb.58.1579

Published

1994-09-00

Pages

1579-83

Language

English

Region

England

NLM ID

9205717

External Links

PubMed source DOI: 10.1271/bbb.58.1579 View journal details

Analysis Services

Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells.

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