Home LiteratureArticle Details
PMID: 7761853 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

Science (New York, N.Y.) ·Vol. 268 ·No. 5215 ·1995-06-02 ·Pages 1343-7

Kündig TM, Bachmann MF, DiPaolo C, Simard JJ, Battegay M, Lother H, Gessner A, Kühlcke K, Ohashi PS, Hengartner H

Abstract

Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

MeSH Terms
Animals Antigen-Presenting Cells/immunology Cytotoxicity, Immunologic Fibroblasts/immunology Glycoproteins/immunology Histocompatibility Antigens Class I/immunology L Cells Lymphocytic Choriomeningitis/immunology Lymphocytic choriomeningitis virus/immunology Lymphoid Tissue/immunology Mice Mice, Inbred C57BL Neoplasms/immunology T-Lymphocytes, Cytotoxic/immunology Transfection Tumor Cells, Cultured Viral Proteins/immunology
Chemicals
Glycoproteins Histocompatibility Antigens Class I Viral Proteins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Kündig T M
Institute of Experimental Immunology, University of Zürich, Switzerland.
Bachmann M F
DiPaolo C
Simard J J
Battegay M
Lother H
Gessner A
Kühlcke K
Ohashi P S
Hengartner H
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.7761853
Published
1995-06-02
Pages
1343-7
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.7761853 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2