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PMID: 7754628 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Biology of human colon cancer metastasis.

World journal of surgery ·Vol. 19 ·No. 2 ·1995-00-00 ·Pages 226-34

Gutman M, Fidler IJ

Abstract

The process of metastasis is highly selective and favors the survival and growth of a few subpopulations of cells that preexist within a heterogeneous primary neoplasm. To produce metastases, tumor cells must succeed in invasion, embolization, survival in the circulation, arrest in a distant capillary bed, and extravasation into and multiplication in organ parenchyma. The outcome of this process depends on the interaction of metastatic cells with multiple host factors. To assess metastatic potential accurately, it is necessary to orthotopically implant human tumor cells recovered from surgical specimens into nude mice. This orthotopic implantation of tumor cells is invariably associated with trauma to the specific organ of implantation, which is followed by the processes of inflammation and repair. Tissue-specific growth factors may be responsible for stimulation of tumor cells that possess specific surface receptors. Understanding the factors that regulate cancer metastasis should allow for the design of rational therapy.

MeSH Terms
Animals Antineoplastic Agents/therapeutic use Cell Survival Colonic Neoplasms/drug therapy,pathology Disease Models, Animal Humans Mice Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Transplantation
Chemicals
Antineoplastic Agents
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gutman M
Department of Cell Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Fidler I J
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Article Info
Journal
World journal of surgery
Abbr.
World J Surg
ISSN
0364-2313
DOI
10.1007/BF00308631
Published
1995-00-00
Pages
226-34
Language
English
Region
United States
NLM ID
7704052
Subset
IM
Grants
NCI NIH HHS · CA 16672 · United States
NCI NIH HHS · R35 CA42107 · United States
External Links
PubMed source DOI: 10.1007/BF00308631 View journal details
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