Leukemic reticuloendotheliosis. A failure of monocyte production.

The New England journal of medicine ·Vol. 295 ·No. 4 ·1976-07-22 ·Pages 181-4

Seshadri RS, Brown EJ, Zipursky A

Abstract

In five cases of leukemic reticuloendotheliosis studied, profound monocytopenia was demonstrable. In 48 normal subjects, monocyte counts ranged from 215 to 921 per cubic millimeter, whereas in the five patients with leukemic reticuloendotheliosis, the counts ranged from 0 to 17 per cubic millimeter. The properties of the "hairy" cell are consistent with those of an incompletely developed monocyte. The susceptibility to infection, characteristics of these patients, may result from a lack of normal monocytes in blood and tissues.

MeSH Terms

Adult Cell Adhesion Erythrocytes Esterases/blood Female Histocytochemistry Humans Immunoglobulin G/analysis Leukemia/immunology Leukemia, Lymphoid/blood Leukemia, Monocytic, Acute/blood,pathology Leukocyte Count Lymphoma, Non-Hodgkin/blood Male Middle Aged Monocytes/enzymology,pathology Phagocytosis Skin Window Technique Spleen/pathology

Chemicals

Immunoglobulin G Esterases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Seshadri R S

Brown E J

Zipursky A

Article Info

Journal

The New England journal of medicine

Abbr.

N Engl J Med

ISSN

0028-4793

DOI

10.1056/NEJM197607222950401

Published

1976-07-22

Pages

181-4

Language

English

Region

United States

NLM ID

0255562

Subset

External Links

PubMed source DOI: 10.1056/NEJM197607222950401 View journal details

Analysis Services

Leukemic reticuloendotheliosis. A failure of monocyte production.

Contact

WeChat Official Account