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PMID: 775091 Published · ppublish English Clinical Trial Comparative Study Journal Article

Polymorphic acetylation of nitrazepam.

Journal of medical genetics ·Vol. 13 ·No. 1 ·1976-02-00 ·Pages 17-9

Karim AK, Evans DA

Abstract

Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).

MeSH Terms

Biotransformation Clinical Trials as Topic Female Humans Male Nitrazepam/metabolism,urine Phenotype Polymorphism, Genetic Sulfamethazine/metabolism

Chemicals

Sulfamethazine Nitrazepam

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Karim A K

Evans D A

References (9)

9 references, click to expand

Genetic control of isoniazid metabolism in man.
Br Med J. 1960 Aug 13;2(5197):485-91 PMID: 13820968
THE INFLUENCE OF ACETYLATOR PHENOTYPE ON THE EFFECTS OF TREATING DEPRESSION WITH PHENELZINE.
Clin Pharmacol Ther. 1965 Jul-Aug;6:430-5 PMID: 14314965
HUMAN ACETYLATION POLYMORPHISM.
J Lab Clin Med. 1964 Mar;63:394-403 PMID: 14164493
The polymorphic acetylation of sulphapyridine in man.
J Med Genet. 1972 Jun;9(2):168-71 PMID: 5046626
Polymorphic acetylation of procaine amide in healthy subjects.
Acta Med Scand. 1975 Apr;197(4):299-302 PMID: 1136858
The polymorphic acetylation of dapsone in man.
Clin Pharmacol Ther. 1971 Mar-Apr;12(2):225-38 PMID: 5554939
[Spectrophotometric determination of 5-phenyl-1,4-benzodiazepine-derivatives and studies on metabolism of nitrazepam. 5. Chemistry and analytics of benzodiazepine-derivatives].
Arzneimittelforschung. 1969 Dec;19(12):1929-31 PMID: 5395884
An improved and simplified method of detecting the acetylator phenotype.
J Med Genet. 1969 Dec;6(4):405-7 PMID: 5365949
Partial purification and properties of the isoniazid transacetylase in human liver. Its relationship to the acetylation of p-aminosalicylic acid.
J Clin Invest. 1965 Dec;44(12):1992-2002 PMID: 5851956

Article Info

Journal

Journal of medical genetics

Abbr.

J Med Genet

ISSN

0022-2593

DOI

10.1136/jmg.13.1.17

Published

1976-02-00

Pages

17-9

Language

English

Region

England

NLM ID

2985087R

PMCID

PMC1013342

Subset

External Links

PubMed source DOI: 10.1136/jmg.13.1.17 PMC Full Text View journal details

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