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PMID: 7750148 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic requirements for initiating asexual development in Aspergillus nidulans.

Current genetics ·Vol. 27 ·No. 1 ·1994-12-00 ·Pages 62-9

Wieser J, Lee BN, Fondon Jw, Adams TH

Abstract

Conidiation in the filamentous ascomycete Aspergillus nidulans requires activation of brlA, a well-characterized transcriptional regulator of genes that are induced specifically during asexual development. We have isolated and characterized developmental mutations in six loci, designated fluG, flbA, flbB, flbC, flbD, and flbE, that result in defective development and reduced brlA expression. These mutants grow indeterminately to produce masses of aerial hyphae resulting in the formation of cotton-like colonies with a "fluffy" morphology. The results of growth and epistasis tests involving all pairwise combinations of fluffy mutations indicate complex hierarchical relationships among these loci. We discuss these genetic interactions and propose that there are multiple mechanisms for activating brlA.

Related Genes
brlA flbA flbB flbC flbD flbE fluG
MeSH Terms
Alleles Aspergillus nidulans/genetics,growth & development,ultrastructure Cloning, Molecular Epistasis, Genetic Fungal Proteins/biosynthesis,genetics,physiology Gene Expression Regulation, Developmental Gene Expression Regulation, Fungal Genes, Fungal Genetic Complementation Test Genetic Linkage Phenotype Promoter Regions, Genetic Recombinant Fusion Proteins/biosynthesis Reproduction, Asexual/genetics Transcription Factors
Chemicals
BRLA protein, Emericella nidulans Fungal Proteins Recombinant Fusion Proteins Transcription Factors
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wieser J
Department of Biology, Texas A & M University, College Station 77843, USA.
Lee B N
Fondon J w
Adams T H
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Article Info
Journal
Current genetics
Abbr.
Curr Genet
ISSN
0172-8083
DOI
10.1007/BF00326580
Published
1994-12-00
Pages
62-9
Language
English
Region
United States
NLM ID
8004904
Subset
IM
Grants
NIGMS NIH HHS · GM45252 · United States
External Links
PubMed source DOI: 10.1007/BF00326580 View journal details
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