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题目:: Identification and kinetics of two recently bone marrow-derived B cell populations in peripheral lymphoid tissues.
作者:: Kroese(F G),de Boer(N K),de Boer(T),Nieuwenhuis(P),Kantor(A B),Deenen(G J)
状态:: 发布时间1995-06-13 , 更新时间 2007-11-14
期刊:: Cell Immunol
摘要:: In rats, the glycoprotein Thy-1 is expressed on recently bone marrow (BM)-generated B cells but not on mature recirculating follicular (RF) B cells. Here we demonstrate that Thy-1+ B cells consist of two phenotypically distinct, but developmentally related, populations: a population of newly formed (NF) B cells (IgMbr-IgDdu) that give rise to the second, less immature, Thy-1+ population of so-called early recirculating follicular (ERF) B cells (Thy-1+IgMduIgDbr) cells. These cells ultimately develop to RF-B cells (Thy-1-IgMbrIgDdu). Kinetic studies reveal that in absolute numbers per day most cells die at the transition of NF-B cells in the BM and those in the periphery: less cells die at later stages of B cell differentiation. Given the notion that this cell loss is not random, we speculate that NF-B cells and ERF-B cells may represent crucial steps during peripheral B cell development and their selection. Identification of their unique phenotype makes it possible to evaluate their roles in development of the antibody repertoire.
语言:: eng
DOI:

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