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PMID: 7737131 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Sequence-dependent bending propensity of DNA as revealed by DNase I: parameters for trinucleotides.

The EMBO journal ·Vol. 14 ·No. 8 ·1995-04-18 ·Pages 1812-8

Brukner I, Sánchez R, Suck D, Pongor S

Abstract

Structural parameters characterizing the bending propensity of trinucleotides were deduced from DNase I digestion data using simple probabilistic models. In contrast to dinucleotide-based models of DNA bending and/or bendability, the trinucleotide parameters are in good agreement with X-ray crystallographic data on bent DNA. This improvement may be due to the fact that the trinucleotide model incorporates more sequence context information than do dinucleotide-based descriptions.

MeSH Terms
Base Sequence Crystallography, X-Ray DNA/chemistry,metabolism Deoxyribonuclease I/metabolism Evaluation Studies as Topic Models, Chemical Molecular Sequence Data Nucleic Acid Conformation Oligodeoxyribonucleotides/chemistry
Chemicals
Oligodeoxyribonucleotides DNA Deoxyribonuclease I
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brukner I
International Centre for Genetic Engineering and Biotechnology, (ICGEB), Trieste, Italy.
Sánchez R
Suck D
Pongor S
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36 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1995-04-18
Pages
1812-8
Language
English
Region
England
NLM ID
8208664
PMCID
PMC398274
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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