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PMID: 7732572 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Nuclear factors in sevenless signalling.

Trends in genetics : TIG ·Vol. 11 ·No. 3 ·1995-03-00 ·Pages 106-11

Dickson B

Abstract

Recent studies in both vertebrates and invertebrates support an 'hourglass' model for signal transduction from receptor tyrosine kinases: Ras channels signals from diverse receptor tyrosine kinases into a common cytoplasmic kinase cascade, the targets of which are an even more diverse collection of nuclear proteins. What are these nuclear factors, and how do they interact to direct specific cellular responses to a generic signal? The past year has brought considerable progress in our quest to answer these questions in one model genetic system, the Drosophila eye.

Related Genes

D-jun Psc RAG1 Ras1 Su(z)2 bmi-1 boss fos fra jun phyl pnt raf ras sev sina yan

MeSH Terms

Animals Cell Differentiation/genetics DNA-Binding Proteins/physiology Drosophila Proteins Drosophila melanogaster/genetics Eye Proteins/genetics,physiology Gene Expression Regulation, Developmental Genes, Insect Membrane Glycoproteins/genetics,physiology Models, Biological Nerve Tissue Proteins Nuclear Proteins/genetics,physiology Phosphorylation Photoreceptor Cells, Invertebrate/growth & development Protein Processing, Post-Translational Proto-Oncogene Proteins/physiology Receptor Protein-Tyrosine Kinases Repressor Proteins Signal Transduction/physiology Transcription Factor AP-1/physiology Transcription Factors Ubiquitin-Protein Ligases

Chemicals

AOP protein, Drosophila DNA-Binding Proteins Drosophila Proteins Eye Proteins Membrane Glycoproteins Nerve Tissue Proteins Nuclear Proteins Proto-Oncogene Proteins Repressor Proteins Transcription Factor AP-1 Transcription Factors phyl protein, Drosophila pnt protein, Drosophila Ubiquitin-Protein Ligases seven in absentia proteins Receptor Protein-Tyrosine Kinases sev protein, Drosophila

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Dickson B

Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

DOI

10.1016/S0168-9525(00)89011-3

Published

1995-03-00

Pages

106-11

Language

English

Region

England

NLM ID

8507085

Subset

External Links

PubMed source DOI: 10.1016/S0168-9525(00)89011-3 View journal details

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