Nevoid basal cell carcinoma syndrome.

Dermatologic clinics ·Vol. 13 ·No. 1 ·1995-01-00 ·Pages 113-25

Gorlin RJ

Abstract

Nevoid basal cell carcinoma syndrome has as its hallmarks such diverse manifestations as numerous cutaneous basal cell cancers and epidermal cysts, palmar and plantar pits, keratocysts of the jaw, calcified dural folds, various skeletal anomalies, cleft lip and/or palate, and various other neoplasms or hamartomas. Inheritance is autosomal dominant. The etiology of all of the above findings appears to be a mutation in a tumor suppressor gene that also plays a role in normal embryonic development.

MeSH Terms

Adolescent Adult Basal Cell Nevus Syndrome/genetics,pathology Bone and Bones/abnormalities Child, Preschool Cleft Lip/genetics,pathology Cleft Palate/genetics,pathology Dura Mater/abnormalities Epidermal Cyst/genetics,pathology Female Foot Dermatoses/genetics,pathology Genes, Tumor Suppressor/genetics Hamartoma/genetics,pathology Hand Dermatoses/genetics,pathology Humans Male Middle Aged Odontogenic Cysts/genetics,pathology Skin Diseases/genetics,pathology Skin Neoplasms/genetics,pathology

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Gorlin R J

Department of Oral Pathology and Genetics, School of Dentistry, University of Minnesota, Minneapolis, USA.

Article Info

Journal

Dermatologic clinics

Abbr.

Dermatol Clin

ISSN

0733-8635

Published

1995-01-00

Pages

113-25

Language

English

Region

United States

NLM ID

8300886

Subset

External Links

PubMed source View journal details

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