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PMID: 7708711 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

A random-walk/giant-loop model for interphase chromosomes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 92 ·No. 7 ·1995-03-28 ·Pages 2710-4

Sachs RK, van den Engh G, Trask B, Yokota H, Hearst JE

Abstract

Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G0/G1 part of the cell cycle may consist of flexible chromatin loops, averaging approximately 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data. More general models consistent with the data are briefly discussed.

MeSH Terms

Base Composition Chromatin/ultrastructure Chromosomes, Human/physiology,ultrastructure Humans In Situ Hybridization, Fluorescence Interphase Models, Genetic Models, Theoretical Polymers Random Allocation

Chemicals

Chromatin Polymers

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Sachs R K

Department of Mathematics, University of California, Berkeley 94720, USA.

van den Engh G

Trask B

Yokota H

Hearst J E

References (8)

8 references, click to expand

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The ratio of dicentrics to centric rings produced in human lymphocytes by acute low-LET radiation.
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Chromosomal "fingerprints" of prior exposure to densely ionizing radiation.
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Polymer models for interphase chromosomes.
Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7854-8 PMID: 8356094
Interchange and intra-nuclear architecture.
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.92.7.2710

Published

1995-03-28

Pages

2710-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC42288

Subset

Grants

NHGRI NIH HHS · HG00256 · United States

NIGMS NIH HHS · R01-GM47945-03 · United States

External Links

PubMed source DOI: 10.1073/pnas.92.7.2710 PMC Full Text View journal details

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A random-walk/giant-loop model for interphase chromosomes.

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