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PMID: 7695282 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae.

Antimicrobial agents and chemotherapy ·Vol. 38 ·No. 12 ·1994-12-00 ·Pages 2908-9

Dhople AM, Ibanez MA, Dhople AA

Abstract

In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.

MeSH Terms
2,2'-Dipyridyl/analogs & derivatives,pharmacology Microbial Sensitivity Tests Mycobacterium leprae/drug effects,growth & development
Chemicals
2,2'-Dipyridyl
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dhople A M
Department of Biological Sciences, Florida Institute of Technology, Melbourne 32901-6988.
Ibanez M A
Dhople A A
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18 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.38.12.2908
Published
1994-12-00
Pages
2908-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC188306
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.38.12.2908 PMC Full Text View journal details
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