Vitronectin and its receptors.

Current opinion in cell biology ·Vol. 5 ·No. 5 ·1993-10-00 ·Pages 864-8

Felding-Habermann B, Cheresh DA

Abstract

The extracellular matrix protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3. Cell interaction with vitronectin may induce spreading and migration and have an effect on cell growth and differentiation in specific processes, such as tumor growth and metastasis, wound healing, bone resorption and viral infection.

MeSH Terms

Animals Apoptosis Bone Resorption Cell Adhesion Cell Differentiation Cell Division Cell Movement Extracellular Matrix Proteins/physiology Glycoproteins/physiology Humans Integrins/physiology Neoplasm Metastasis Neoplasms/pathology Receptors, Cytoadhesin/physiology Receptors, Vitronectin Signal Transduction Vitronectin

Chemicals

Extracellular Matrix Proteins Glycoproteins Integrins Receptors, Cytoadhesin Receptors, Vitronectin Vitronectin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Felding-Habermann B

Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037.

Cheresh D A

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/0955-0674(93)90036-p

Published

1993-10-00

Pages

864-8

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/0955-0674(93)90036-p View journal details

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