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PMID: 7689220 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 16 ·1993-08-15 ·Pages 7508-12

Kimura H, Schubert D

Abstract

The biological function of the soluble form of the amyloid beta-protein (ABP) was examined by assaying its interaction with neuronal receptors expressed in Xenopus oocytes. ABP weakly activated tachykinin receptors, but in the presence of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4- propionate-type glutamate receptors ABP-induced responses were greatly enhanced. Glutamate and ABP together also induced accumulation of inositol trisphosphate and increases in intracellular Ca2+. These observations suggest that in the presence of glutamate, ABP can activate tachykinin receptors and phosphatidylinositol turnover. ABP may therefore act as a neuromodulatory peptide.

MeSH Terms
2-Amino-5-phosphonovalerate/pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione Amino Acid Sequence Amyloid beta-Peptides/pharmacology Analgesics/pharmacology Animals Calcium/pharmacology Drug Synergism Female Glutamates/pharmacology Glutamic Acid Inositol 1,4,5-Trisphosphate/metabolism Kinetics Molecular Sequence Data Neurons/physiology Oocytes/metabolism Quinoxalines/pharmacology RNA, Messenger/metabolism Receptors, AMPA Receptors, Glutamate/biosynthesis,drug effects,metabolism Receptors, N-Methyl-D-Aspartate/biosynthesis,drug effects,metabolism Receptors, Neurokinin-1 Receptors, Neurotransmitter/biosynthesis,drug effects,metabolism Sodium/pharmacology Substance P/analogs & derivatives,pharmacology Xenopus
Chemicals
Amyloid beta-Peptides Analgesics Glutamates Quinoxalines RNA, Messenger Receptors, AMPA Receptors, Glutamate Receptors, N-Methyl-D-Aspartate Receptors, Neurokinin-1 Receptors, Neurotransmitter Substance P Glutamic Acid 6-Cyano-7-nitroquinoxaline-2,3-dione 2-Amino-5-phosphonovalerate Inositol 1,4,5-Trisphosphate spantide Sodium Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kimura H
Salk Institute, San Diego, CA 92186-5800.
Schubert D
References (35)
35 references, click to expand
  1. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
    Nature. 1991 Feb 21;349(6311):704-6 PMID: 1671712
  2. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.
    Science. 1993 Jan 22;259(5094):514-6 PMID: 8424174
  3. Biological evaluation of substance P antagonists.
    Br J Pharmacol. 1984 Oct;83(2):449-56 PMID: 6207886
  4. Amyloid plaque core protein in Alzheimer disease and Down syndrome.
    Proc Natl Acad Sci U S A. 1985 Jun;82(12):4245-9 PMID: 3159021
  5. Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain.
    J Neurosci. 1985 Dec;5(12):3270-7 PMID: 4078628
  6. Regulation of brain type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch.
    Cell. 1986 Mar 28;44(6):861-70 PMID: 3006921
  7. Neurotensin and substance P receptors expressed in Xenopus oocytes by messenger RNA from rat brain.
    Proc R Soc Lond B Biol Sci. 1986 Nov 22;229(1255):151-9 PMID: 2433695
  8. cDNA cloning of bovine substance-K receptor through oocyte expression system.
    Nature. 1987 Oct 29-Nov 4;329(6142):836-8 PMID: 2823146
  9. Distribution of protein kinase C-like immunoreactive neurons in rat brain.
    J Neurosci. 1988 Feb;8(2):369-82 PMID: 3276831
  10. An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation.
    Nature. 1989 Aug 17;340(6234):554-7 PMID: 2549423
  11. Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
    Science. 1989 Aug 25;245(4920):862-6 PMID: 2549638
  12. Molecular characterization of a functional cDNA for rat substance P receptor.
    J Biol Chem. 1989 Oct 25;264(30):17649-52 PMID: 2478537
  13. Cloning by functional expression of a member of the glutamate receptor family.
    Nature. 1989 Dec 7;342(6250):643-8 PMID: 2480522
  14. Cloning and expression of a rat neuromedin K receptor cDNA.
    J Biol Chem. 1990 Jan 15;265(2):623-8 PMID: 2153106
  15. Cleavage of amyloid beta peptide during constitutive processing of its precursor.
    Science. 1990 Jun 1;248(4959):1122-4 PMID: 2111583
  16. Structure and functional expression of the cloned rat neurotensin receptor.
    Neuron. 1990 Jun;4(6):847-54 PMID: 1694443
  17. Latencies of membrane currents evoked in Xenopus oocytes by receptor activation, inositol trisphosphate and calcium.
    J Physiol. 1989 Aug;415:189-210 PMID: 2484206
  18. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
    Science. 1990 Oct 12;250(4978):279-82 PMID: 2218531
  19. Tissue distribution and quantitation of the mRNAs for three rat tachykinin receptors.
    Eur J Biochem. 1990 Nov 13;193(3):751-7 PMID: 1701145
  20. Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage.
    Brain Res. 1990 Nov 19;533(2):315-20 PMID: 2289145
  21. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors.
    Nature. 1991 Apr 11;350(6318):505-8 PMID: 1849616
  22. Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition.
    Science. 1991 May 10;252(5007):851-3 PMID: 1709304
  23. The characterization and localization of the glutamate receptor subunit GluR1 in the rat brain.
    J Neurosci. 1991 Sep;11(9):2713-24 PMID: 1652625
  24. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.
    Science. 1991 Oct 4;254(5028):97-9 PMID: 1925564
  25. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
    Nature. 1991 Oct 31;353(6347):844-6 PMID: 1944558
  26. Molecular cloning and characterization of the rat NMDA receptor.
    Nature. 1991 Nov 7;354(6348):31-7 PMID: 1834949
  27. beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity.
    J Neurosci. 1992 Feb;12(2):376-89 PMID: 1346802
  28. Amyloid beta-protein fragment 25-35 causes activation of cytoplasmic calcium in neurons.
    Biochem Biophys Res Commun. 1992 May 15;184(3):1441-7 PMID: 1590803
  29. Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.
    Science. 1992 Jul 10;257(5067):201-6 PMID: 1378648
  30. Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance P/substance K receptors.
    EMBO J. 1992 Oct;11(10):3585-91 PMID: 1382977
  31. Amyloid beta-peptide is produced by cultured cells during normal metabolism.
    Nature. 1992 Sep 24;359(6393):322-5 PMID: 1383826
  32. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids.
    Nature. 1992 Sep 24;359(6393):325-7 PMID: 1406936
  33. Production of the Alzheimer amyloid beta protein by normal proteolytic processing.
    Science. 1992 Oct 2;258(5079):126-9 PMID: 1439760
  34. Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide.
    Nature. 1993 Jan 21;361(6409):260-3 PMID: 7678698
  35. Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane.
    J Physiol. 1982 Jul;328:143-70 PMID: 7131311
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.16.7508
Published
1993-08-15
Pages
7508-12
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC47171
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.90.16.7508 PMC Full Text View journal details
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