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PMID: 7676647 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Molecular comparison of coxsackie A virus serotypes.

Virology ·Vol. 212 ·No. 1 ·1995-09-10 ·Pages 30-8

Pulli T, Koskimies P, Hyypiä T

Abstract

Genetic diversity of coxsackie A viruses (CAVs) and enteroviruses 68, 69, and 71 was studied by comparing nucleotide and derived amino acid sequences from the 5' untranslated region (5'UTR), VP4-VP2 capsid protein and polymerase 3D region, and 3'UTR. The data were obtained by sequencing PCR amplicons. According to the molecular analysis of the coding region, CAVs belong to three different genetic clusters. CAV2, 3, 5, 7, 8, 10, 12, 14, and 16 form a coherent genetic group designated cluster A. No other enteroviruses, apart from enterovirus 71, are found in this cluster. CAV9 is the only member of the subgroup found in the same genetic group with coxsackie B viruses, the major group of echoviruses and enterovirus 69 (cluster B). Cluster C includes CAV1, 11, 13, 15, 17, 18, 19, 20, 21, 22, and 24 which are genetically close relatives of polioviruses. Enterovirus 68 is related to enterovirus 70 (cluster D). Clusters different from those in the coding region are found in the 5'UTR while the grouping in the 3'UTR is similar to that found in the capsid region. Correlation of these findings with evolution, pathogenesis, and classification is discussed.

MeSH Terms
Base Sequence DNA Primers/chemistry Enterovirus/classification,genetics Genes, Viral Intercellular Adhesion Molecule-1/metabolism Molecular Sequence Data Phylogeny RNA, Viral/genetics Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Serotyping Viral Structural Proteins/genetics
Chemicals
DNA Primers RNA, Viral Viral Structural Proteins Intercellular Adhesion Molecule-1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pulli T
Department of Virology, University of Turku, Finland.
Koskimies P
Hyypiä T
Article Info
Journal
Virology
Abbr.
Virology
ISSN
0042-6822
DOI
10.1006/viro.1995.1450
Published
1995-09-10
Pages
30-8
Language
English
Region
United States
NLM ID
0110674
Subset
IM
Databases
GENBANK
X87584, X87585, X87586, X87587, X87588, X87589, X87590, X87591, X87592, X87593, X87594, X87595, X87596, X87597, X87598, X87599, X87600, X87601, X87602, X87603, X87604, X87605, X87606
External Links
PubMed source DOI: 10.1006/viro.1995.1450 View journal details
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