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PMID: 7662098 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Isohormonal therapy of endocrine autoimmunity.

Immunology today ·Vol. 16 ·No. 6 ·1995-06-00 ·Pages 289-94

Schloot N, Eisenbarth GS

Abstract

For most autoimmune disorders, the site (if any) of chronic immunization required for perpetuation of autoimmunity is unknown. However, one possible site is the target organ itself. If this were the case, feedback regulation of target cell activity might influence autoimmunity. Here, Nanette Schloot and George Eisenbarth review several recent studies suggesting that therapies that inhibit hormonal secretion of target endocrine organs, and/or modulate immunity by therapy with the isohormone, are associated with disease suppression.

MeSH Terms
Addison Disease/drug therapy,immunology Animals Autoimmune Diseases/drug therapy,immunology Diabetes Mellitus, Type 1/drug therapy,genetics Disease Models, Animal Drug Evaluation, Preclinical Endocrine System Diseases/drug therapy,immunology Feedback Graves Disease/drug therapy,immunology Hormones/therapeutic use Humans Insulin/therapeutic use Islets of Langerhans/drug effects,immunology,physiopathology Mice Mice, Inbred NOD Organ Specificity Randomized Controlled Trials as Topic Rats Rats, Inbred BB Thyroiditis, Autoimmune/drug therapy,immunology
Chemicals
Hormones Insulin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schloot N
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA.
Eisenbarth G S
Article Info
Journal
Immunology today
Abbr.
Immunol Today
ISSN
0167-5699
DOI
10.1016/0167-5699(95)80183-9
Published
1995-06-00
Pages
289-94
Language
English
Region
England
NLM ID
8008346
Subset
IM
Grants
NIDDK NIH HHS · DK32083 · United States
NIDDK NIH HHS · DK43279 · United States
NCRR NIH HHS · RR00069 · United States
External Links
PubMed source DOI: 10.1016/0167-5699(95)80183-9
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